catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,enzyme regulation:Activated by CHAPS.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester.,PTM:Contains sialic acid.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Homotrimer and homohexamer. Binds to beta-glucuronidase.,tissue specificity:Expressed predominantly in liver with lower levels in heart and lung.,
Endoplasmic reticulum lumen . Cytoplasm . Lipid droplet . Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets. .
Expressed predominantly in liver with lower levels in heart and lung (PubMed:10562416). Expressed in macrophages (PubMed:11015575, PubMed:21049984, PubMed:18762277).
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