cofactor:Binds 1 magnesium ion per subunit .,function:Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.,similarity:Belongs to the phosphohexose mutase family.,subcellular location:Adherens-type cellular junctions.,subunit:Interacts with cytoskeletal proteins dystrophin and utrophin.,tissue specificity:Expressed in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component.,
Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell membrane, sarcolemma . Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments. .
Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level).
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