catalytic activity:Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.,cofactor:Pyridoxal phosphate.,function:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.,tissue specificity:Found in liver and kidney.,
Endoplasmic reticulum membrane ; Single-pass type III membrane protein ; Cytoplasmic side .
Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).
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