catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.,PTM:N-glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,tissue specificity:Expressed in liver, colon and small intestine.,
Endoplasmic reticulum lumen .
Expressed in liver, colon and small intestine.
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