GALT2 rabbit pAb

catalytic activity:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.,cofactor:Calcium.,cofactor:Manganese.,domain:The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.,domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,function:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.,online information:GlycoGene database,online information:Polypeptide N-acetylgalactosaminyltransferase 2,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.,similarity:Contains 1 ricin B-type lectin domain.,subcellular location:Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.,tissue specificity:Widely expressed.,