function:Component of the exosome 3'->5' exoribonuclease complex. Required for the 3'-processing of the 7S pre-RNA to the mature nuclear complex. Also associated with the GTPase Ran. Has a 3'-5' exonuclease activity.,similarity:Belongs to the ribonuclease II (RNB) family.,similarity:Contains 1 PINc domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: RRP4, RRP40, RRP41/SKI6, RRP42, RRP43, RRP44/DIS3, PM/Scl-75, RRP46, CSL4 and PM/Scl-100 (only in the nuclear complex). Also associated with the GTPase Ran.,tissue specificity:Widely expressed.,
Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus . Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). .
Widely expressed.
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