function:In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.,similarity:Belongs to the BRAG family.,similarity:Contains 1 IQ domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SEC7 domain.,subcellular location:At steady state, may be preferentially cytosolic.,subunit:Interacts with ARF6.,tissue specificity:Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.,
Cytoplasm . Nucleus . Cell junction, synapse, postsynaptic density . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . At steady state, may be preferentially cytosolic.
Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
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