PCSK6 rabbit pAb

catalytic activity:Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.,cofactor:Calcium .,domain:The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain.,function:Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 homo B/P domain.,similarity:Contains 1 PLAC domain.,subcellular location:Not secreted, remains probably in zymogen form in endoplasmic reticulum.,subcellular location:Retained intracellularly probably through a hydrophobic cluster in their C-terminus.,subunit:The PACE4A-I precursor protein seems to exist in the reticulum endoplasmic as both a monomer and a dimer-sized complex whereas mature PACE4A-I exists only as a monomer, suggesting that propeptide cleavage affects its tertiary or quaternary structure.,tissue specificity:Each PACE4 isoform exhibits a unique restricted distribution. PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. PACE4A-II is at least expressed in placenta. PACE4B was only found in the embryonic kidney cell line from which it was isolated. PACE4C and PACE4D are expressed in placenta. PACE4E-I is expressed in cerebellum, placenta and pituitary. PACE4E-II is at least present in cerebellum.,