caution:Was originally (Ref.3, AAO26699) thought to originate from mouse.,function:Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility.,induction:Repressed by tunicamycin, an inhibitor of N-glycosylation.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anionic channels and transporters), gluconate, and by thiosulfate.,PTM:N-glycosylated.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 STAS domain.,subcellular location:Located at the annulus ring structure within the sperm cell.,subunit:Interacts with RACGAP1.,tissue specificity:Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.,
Membrane ; Multi-pass membrane protein . Located at the annulus ring structure within the sperm cell. .
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa.
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