function:Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.,PTM:N-glycosylated.,PTM:Phosphorylated by PKA.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 6 ANK repeats.,subcellular location:Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA.,
Cell membrane ; Multi-pass membrane protein . Cytoplasm . Melanosome . Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Brain,Lymphoblast,Skin,
下载说明书
