function:May function as a transcription factor.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,tissue specificity:Testis-specific. Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL.,
[Isoform 1]: Nucleus . Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). .; [Isoform 2]: Nucleus . Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). .
Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151).
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