miscellaneous:Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpresseed in 80% of colorectal cancers.,PTM:Sumoylated.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 10 C2H2-type zinc fingers.,subunit:Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.,tissue specificity:Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney.,
Nucleus .
Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.
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