LPP3 rabbit pAb

catalytic activity:A 3-sn-phosphatidate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.,enzyme regulation:Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment.,function:Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.,induction:By epidermal growth factor (EGF), vascular endothelial growrh factor (VEGF), basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA).,PTM:N-glycosylated. Contains high-mannose oligosaccharides.,similarity:Belongs to the PA-phosphatase related phosphoesterase family.,subunit:Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.,tissue specificity:Ubiquitously expressed. Highly expressed in heart and placenta.,