LFTY2 rabbit pAb

developmental stage:Transiently expressed before and during menstrual bleeding.,disease:Defects in LEFTY2 are the cause of left-right axis malformations (L-R axis malformation) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.,function:Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,sequence caution:Authors have revised their sequence, but have not submitted the revised DNA sequence.,similarity:Belongs to the TGF-beta family.,tissue specificity:Mesenchymal cells of the endometrial stroma.,