function:May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.,sequence caution:Intron retention.,similarity:Belongs to the protein disulfide isomerase family.,similarity:Contains 2 thioredoxin domains.,subunit:Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA.,tissue specificity:Widely expressed at low level. Expressed at higher level in thyroid and prostate.,
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Widely expressed at low level. Expressed at higher level in thyroid and prostate.
下载说明书
