domain:Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).,domain:The C-terminal domain (AA 443-731) contains a nuclear export signal.,function:Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.,subcellular location:Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.,subunit:Interacts with ESR1, PBX1, PBX2 and PBX3.,tissue specificity:Expressed in early hematopietic precursors.,
Cytoplasm, cytoskeleton . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
Expressed in early hematopoietic precursors.
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