disease:Defects in DOCK4 are involved in the cause of some cancers, which are probably due to lack of Rap1 activation.,domain:The DHR-2 domain probably mediates the GEF activity.,function:Involved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.,miscellaneous:Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1.,tissue specificity:Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.,
Cell membrane . Cell projection . Cytoplasm, cytosol . Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. .
Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. ; [Isoform 2]: May be specifically expressed in the brain and eye.
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