domain:C-terminal zinc fingers mediate homodimerization.,domain:The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.,function:DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.,miscellaneous:'Pegasus' was the winged horse in Greek mythology.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Self-associates and interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.,tissue specificity:Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K562. Highly expressed in THP-1 and Mo7e-IL3 cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.,
Nucleus .
Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
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