UBC12 rabbit pAb

catalytic activity:ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine.,domain:Both the N-terminal docking peptide and the catalytic core domain must bind the uba3-nae1 complex simultaneously for optimal transfer of nedd8.,function:Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation.,pathway:Protein modification; protein neddylation.,similarity:Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.,subunit:Interacts with UBA3 and RBX1.,