developmental stage:Expression may increase during differentiation.,function:May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.,induction:Expression is induced by sodium butyrate, an inhibitor of colon cancer cell proliferation.,PTM:Phosphorylated.,similarity:Belongs to the CCNDBP1 family.,subunit:Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.,tissue specificity:Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.,
Cytoplasm. Nucleus.
Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
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