function:May be involved in mitochondrial iron-sulfur protein biosynthesis.,miscellaneous:Reduction of LYRM4 levels by siRNA increases the total iron content, and reduces cytosolic and mitochondrial aconitase activities and NFS1 protein levels.,pathway:Cofactor biosynthesis; iron-sulfur cluster biosynthesis.,similarity:Belongs to the complex I LYR family.,subunit:Interacts with FXN. Interaction is increased by nickel. Interaction is inhibited by calcium, magnesium, manganese, copper, cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form of NFS1. The complex increased the stability of NFS1.,tissue specificity:Reduced mRNA levels in Friedreich ataxia (FA) patients.,
Mitochondrion. Nucleus.
Reduced mRNA levels in Friedreich ataxia patients.
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