domain:The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.,function:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.,similarity:Belongs to the Homer family.,similarity:Contains 1 WH1 domain.,subcellular location:Postsynaptic density of neuronal cells.,subunit:Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.,
Cytoplasm . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Postsynaptic density of neuronal cells. .
下载说明书
