function:E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.,pathway:Protein modification; protein ubiquitination.,sequence caution:Translated as Gln.,similarity:Belongs to the UBR1 family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UBR-type zinc finger.,subunit:Interacts with UBE2A and UBE2B.,
Membrane ; Multi-pass membrane protein .
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