function:Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis.,miscellaneous:In contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in human.,similarity:Belongs to the IMPACT family.,similarity:Contains 1 RWD domain.,subunit:Interacts with GCN1/GCN1L1.,tissue specificity:Widely expressed. Expressed at high level in brain.,
Cytoplasm .
Widely expressed. Expressed at high level in brain.
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