caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,enzyme regulation:Inhibited by the general metalloprotease inhibitors o-phenanthroline and batimastat. Also significantly inhibited by amastatin, which is an inhibitor of aminopeptidases. Not inhibited by 4-(2-aminoethyl)-benzenesulfonyl fluoride, E-64, and TIMPS (tissue inhibitors of metalloproteinases), which are inhibitors of serine, cysteine, and matrix metalloproteases, respectively.,function:Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.,sequence caution:Translated as Gly.,similarity:Belongs to the peptidase archaemetzincin family.,tissue specificity:Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver, pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain.,
Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS).
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