disease:In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.,function:Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.,PTM:N-glycosylated.,similarity:Belongs to the alpha-2-MRAP family.,subcellular location:Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.,subunit:Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation.,
Rough endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment lumen . Golgi apparatus, cis-Golgi network . Golgi apparatus lumen . Endosome lumen . Cell surface . May be associated with receptors at the cell surface. .
下载说明书
