disease:Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM) [MIM:601295]. PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels.,function:Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.,similarity:Belongs to the sodium:bile acid symporter family.,subunit:Monomer and homodimer.,
Membrane; Multi-pass membrane protein.
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