function:Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.,similarity:Belongs to the secY/SEC61-alpha family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.,
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes exclusively in granular structures in the endoplasmic reticulum (ER). .
Expressed in proximal and distal tubules in kidney (at protein level).
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