VPRBP rabbit pAb

domain:Although not canonical, the WD repeat-like region is related to WD repeats.,function:May act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 and arrest the cell cycle in G2 phase.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the VPRBP family.,similarity:Contains 1 LisH domain.,subunit:Interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex. In case of infection, interacts with HIV-1 virus Vpr protein and forms a ternary complex with HIV-1 Vpr and DDB1.,tissue specificity:Ubiquitously expressed.,