function:Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1.,miscellaneous:'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.,similarity:Belongs to the akirin family.,subunit:Interacts with YWHAB.,tissue specificity:Widely expressed with the highest expression in peripheral blood leukocytes.,
Nucleus . Cytoplasm . Membrane . Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. .
Widely expressed with the highest expression in peripheral blood leukocytes.
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