domain:Calcium may be bound by the cadherin-like repeats .,function:Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.,similarity:Contains 5 cadherin domains.,tissue specificity:Strongly expressed in epidermis, less in lymph node and tongue.,
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Strongly expressed in epidermis, less in lymph node and tongue.
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