OSBP1 rabbit pAb

domain:The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.,domain:The second coiled-coil domain is required for interaction with the tyrosine phosphatase.,function:Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.,similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,subcellular location:When bound to oxysterols, translocates to the periphery of Golgi membranes.,subunit:Homodimer or homotrimer.,tissue specificity:Widely expressed.,