RN5A rabbit pAb

catalytic activity:Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.,cofactor:Manganese or magnesium. Required for optimal RNA cleavage rates.,disease:Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) [MIM:176807, 601518].,domain:The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain.,domain:The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.,enzyme regulation:After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor.,function:Endoribonuclease, mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.,induction:By interferons.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 ANK repeats.,subunit:Monomer (inactive form) or homodimer.,tissue specificity:Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.,