function:May play an important role in maintaining normal growth homeostasis in epithelial cells.,induction:Up-regulated by butyrate, trichostatin A and 5'-aza-2' deoxycytidine.,tissue specificity:Abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues.,
Secreted . Endoplasmic reticulum .
Highly expressed in the intestinal epithelial cells (at protein level) (PubMed:32629119). Abundantly expressed in the epithelial cells of the liver, kidney and cervix. Significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level).
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