caution:In contrast to other members of the family, it lacks the C-terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. Its precise function is therefore unsure.,cofactor:Calcium.,cofactor:Manganese.,domain:There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.,function:May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.,online information:GlycoGene database,online information:Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.,tissue specificity:Expressed in testis.,
Late endosome membrane ; Single-pass type II membrane protein . Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). .
Mainly expressed in testis. Weakly or not expressed in other tissues.
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