caution:It is uncertain whether Met-1 or Met-4 is the initiator.,function:Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator.,induction:Up-regulated by activation of alpha1-adrenergic receptors.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 13 C2H2-type zinc fingers.,subunit:Binds DNA. Interacts with GATA4.,
Nucleus .
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