function:Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes.,similarity:Belongs to the AB hydrolase superfamily. Lipase family.,subunit:Monomer.,tissue specificity:Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.,
[Isoform 1]: Nucleus . Colocalizes with PCNA at replication foci (PubMed:21398629). Relocalizes to the cytoplasm in response to DNA damage (PubMed:16460818). .; [Isoform 2]: Cytoplasm . Translocates to the nucleus in response to DNA damage. .; [Isoform 3]: Cytoplasm .; [Isoform 4]: Cytoplasm . Mitochondrion .; [Isoform 5]: Mitochondrion matrix .
Ubiquitously expressed.
下载说明书
