catalytic activity:RNA processing activity that hydrolyzes the 2'-5' phosphodiester linkage at the branchpoint of excised intron lariats.,cofactor:Divalent metal cations.,function:Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis.,miscellaneous:Cells lacking DBR1 show an inhibition of HIV-1 replication.,similarity:Belongs to the lariat debranching enzyme family.,
Nucleus .
Ubiquitously expressed, strongest expression in the spinal cord and brainstem.
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