caution:The gene encoding this protein shares one overlapping exon with TMEM113.,function:Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3.,similarity:Belongs to the WD repeat SWD2 family.,similarity:Contains 6 WD repeats.,subunit:Interacts with CUL4B. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1.,
Nucleus . Chromosome . Associates with chromatin (PubMed:20516061). Recruited at sites of high RNA polymerase II occupancy (By similarity). .
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