Cytoplasm . Nucleus .; [Isoform 1]: Cell projection, lamellipodium . Cell projection, filopodium . Cytoplasm, cytoskeleton . Cell junction, adherens junction . Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips (PubMed:11516653, PubMed:15572692). Present at nascent adherens junctions, where it clusters adjacent to the tips of F-actin protrusions (PubMed:15572692). .
Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
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