Endomembrane system. Cell junction. Cell junction, tight junction. Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.
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