[Surface protein]: Cell membrane ; Peripheral membrane protein . The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. .; [Transmembrane protein]: Cell membrane ; Single-pass type I membrane protein .; [Syncytin-1]: Virion .
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
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