Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side . The association with ERP44 may be essential for its retention in the endoplasmic reticulum.
Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level). Detected at low level in many other tissues.
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