function:Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 24 LRR (leucine-rich) repeats.,subunit:Binds MYD88 via their respective TIR domains.,tissue specificity:Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.,
Endosome membrane ; Single-pass type I membrane protein . Endosomal localization confers distinctive proteolytic processing. .
Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells.
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