Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth . Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism . It may also have a role in the development of malignancy and the growth progression of some tumors.
Cytoplasm . Nucleus . Cytoplasm, cytosol . Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion. .
IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.
下载说明书
