Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis . HMGCR is the main target of statins, a class of cholesterol-lowering drugs .
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Multi-pass membrane protein .
[Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland. ; [Isoform 2]: Detected in the cerebellum, fetal brain, testis and adrenal gland. ; [Isoform 3]: Low abundance except in skin, esophagus, and uterine cervix.
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