Mediates the anchoring of the endoplasmic reticulum to microtubules. ; High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
Endoplasmic reticulum membrane ; Single-pass type II membrane protein. Cell membrane ; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Translocates to the perinuclear region upon APF-stimulation.