Essential for the organization of sarcomeric actin thin filaments in skeletal muscle . Increases the rate of actin polymerization .
Cytoplasm . Cytoplasm, myofibril, sarcomere, M line . Cytoplasm, myofibril, sarcomere, A band . Cytoplasm, cytoskeleton . Highly expressed in nonstriated areas of developing myotubes, where it shows a granular cytoplasmic pattern. In sarcomeres, highly expressed in the M band region and, at lower levels, along actin thin filaments. Not detected in Z-disks. In sarcomeres, may be located near, but not at, actin thin filament pointed end. .
Expressed in cardiac and at higher levels in skeletal muscles (at protein level).
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