Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide . Plays a role in disulfide bond formation in a variety of extracellular proteins . In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration .
[Isoform 1]: Golgi apparatus membrane ; Single-pass membrane protein . Secreted . A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. .; [Isoform 2]: Secreted . Found in the extracellular medium of quiescent cells but is not found in proliferating cells. .
Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.
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