Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate . Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate . Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable).
Mitochondrion inner membrane ; Multi-pass membrane protein .
下载说明书
